Biased antagonism of CXCR4 avoids antagonist tolerance

Hitchinson, B; Eby, JM; Gao, XL; Guite-Vinet, F; Ziarek, JJ; Abdelkarim, H; Lee, Y; Okamoto, Y; Shikano, S; Majetschak, M; Heveker, N; Volkman, BF; Tarasova, NI; Gaponenko, V

Gaponenko, V (reprint author), Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL 60607 USA.

SCIENCE SIGNALING, 2018; 11 (552):

Abstract

Repeated dosing of drugs targeting G protein-coupled receptors can stimulate antagonist tolerance, which reduces their efficacy; thus, strategies to a......

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