Noninvasive Detection of Polyclonal Acquired Resistance to FGFR Inhibition in Patients With Cholangiocarcinoma Harboring FGFR2 Alterations

Varghese, AM; Patel, J; Janjigian, YY; Meng, FL; Selcuklu, SD; Iyer, G; Houck-Loomis, B; Harding, JJ; O'Reilly, EM; Abou-Alfa, GK; Lowery, MA; Berger, MF

Varghese, AM (corresponding author), Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.; Varghese, AM (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Med, Gastrointestinal Oncol Serv, Div Solid Tumor Oncol, 300 East 66th St, New York, NY 10065 USA.

JCO PRECISION ONCOLOGY, 2021; 5 (): 44

Abstract

PURPOSE Fibroblast growth factor receptor (FGFR) 2 alterations, present in 5%-15% of intrahepatic cholangiocarcinomas (IHC), are targets of FGFR-direc......

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