Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

Marek, M; Shaik, TB; Heimburg, T; Chakrabarti, A; Lancelot, J; Ramos-Morales, E; Da Veiga, C; Kalinin, D; Melesina, J; Robaa, D; Schmidtkunz, K; Suzuki, T; Holl, R; Ennifar, E; Pierce, RJ; Jung, M; Sippl, W; Romier, C

Marek, M; Romier, C (reprint author), Univ Strasbourg, IGBMC, CNRS, INSERM,UMR7104,U1258,Dept Biol Struct Integrat, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France.; Marek, M (reprint author), Japan Sci & Technol Agcy JST, CREST, 4-1-8 Honcho,

JOURNAL OF MEDICINAL CHEMISTRY, 2018; 61 (22): 10000

Abstract

Metal-dependent histone deacetylases (HDACs) are key epigenetic regulators that represent promising therapeutic targets for the treatment of numerous ......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索