Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion

Garcia-Agudo, LF; Janova, H; Sendler, LE; Arinrad, S; Steixner, AA; Hassouna, I; Balmuth, E; Ronnenberg, A; Schopf, N; van der Flier, FJ; Begemann, M; Martens, H; Weber, MS; Boretius, S; Nave, KA; Ehrenreich, H

Ehrenreich, H (reprint author), Max Planck Inst Expt Med, Clin Neurosci, Hermann Rein Str 3, D-37075 Gottingen, Germany.; Nave, KA (reprint author), Max Planck Inst Expt Med, Dept Neurogenet, Hermann Rein Str 3, D-37075 Gottingen, Germany.

FASEB JOURNAL, 2019; 33 (7): 8634

Abstract

Reduced expression of 2'-3 '-cyclic nucleotide 3 '-phosphodiesterase (Cnp) in humans and mice causes white matter inflammation and catatonic signs. Th......

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