Scaffold hopping from indoles to indazoles yields dual MCL-1/BCL-2 inhibitors from MCL-1 selective leads

Drennen, B; Goodis, CC; Bowen, N; Yu, WB; Vickers, G; Wilder, PT; MacKerell, AD; Fletcher, S

Fletcher, S (通讯作者)，Univ Maryland, Dept Pharmaceut Sci, Sch Pharm, 20 N Pine St, Baltimore, MD 21201 USA.;Fletcher, S (通讯作者)，Univ Maryland, Greenebaum Canc Ctr, 20 S Greene St, Baltimore, MD 21201 USA.

RSC MEDICINAL CHEMISTRY, 2022; 13 (8): 963

Abstract

Overexpression of the anti-apoptotic BCL-2 proteins is associated with the development and progression of a range of cancers. Venetoclax, an FDA-appro......

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