Nuclear Respiratory Factor-1, a Novel SMAD4 Binding Protein, Represses TGF-beta/SMAD4 Signaling by Functioning as a Transcriptional Cofactor

Rajasekaran, N; Song, K; Lee, JH; Wei, Y; Erkin, OC; Lee, H; Shin, YK

Shin, YK (corresponding author), Seoul Natl Univ, Pharmaceut Sci Res Inst, Lab Mol Pathol & Canc Genom, Seoul 08826, South Korea.; Shin, YK (corresponding author), Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea.; Shin, YK (corresponding author), Seoul Natl Univ, Dept Mol Med & Biopharmaceut Sci, Grad Sch Convergence Sci & Technol, Seoul 08826, South Korea.; Shin, YK (corresponding author), Seoul Natl Univ, Bio MAX, Seoul 08826, South Korea.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021; 22 (11):

Abstract

SMAD4, a key regulator of transforming growth factor-beta (TGF-beta) signaling, plays a major role in cell growth, migration, and apoptosis. In partic......

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