CYP Suppression in Human Hepatocytes by Monomethyl Auristatin E, the Payload in Brentuximab Vedotin (Adcetris(A (R))), is Associated with Microtubule Disruption

Wolenski, FS; Xia, CQ; Ma, BL; Han, TH; Shyu, WC; Balani, SK

Balani, SK (reprint author), Takeda Pharmaceut Int Co, Drug Metab & Pharmacokinet, 35 Landsdowne St, Cambridge, MA 02139 USA.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2018; 43 (3): 347

Abstract

Monomethyl auristatin E (MMAE), the toxin linked to CD30-specific monoclonal antibody of Adcetris(A (R)) (brentuximab vedotin), is a potent anti-micro......

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