Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

Rios-Doria, J; Harper, J; Rothstein, R; Wetzel, L; Chesebrough, J; Marrero, A; Chen, C; Strout, P; Mulgrew, K; McGlinchey, K; Fleming, R; Bezabeh, B; Meekin, J; Stewart, D; Kennedy, M; Martin, P; Buchanan, A; Dimasi, N; Michelotti, E; Hollingsworth,

Rios-Doria, J (reprint author), MedImmune, One MedImmune Way, Gaithersburg, MD 20878 USA.

CANCER RESEARCH, 2017; 77 (10): 2686

Abstract

Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates the immune sy......

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