VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

Abdulmalik, O; Pagare, PP; Huang, BS; Xu, GG; Ghatge, MS; Xu, XM; Chen, QK; Anabaraonye, N; Musayev, FN; Omar, AM; Venitz, J; Zhang, Y; Safo, MK

Abdulmalik, O (corresponding author), Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA.; Safo, MK (corresponding author), Virginia Commonwealth Univ, Dept Med Chem, Richmond, VA 23298 USA.; Safo, MK (corresponding author), Virginia Commonwealth Univ, Sch Pharm, Inst Struct Biol Drug Discovery & Dev, Richmond, VA 23298 USA.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

Sickle cell disease (SCD) results from a hemoglobin (Hb) mutation beta Glu6 -> beta Val6 that changes normal Hb (HbA) into sickle Hb (HbS). Under h......

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