Anti-PD1 "SHR-1210' aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement

Finlay, WJJ; Coleman, JE; Edwards, JS; Johnson, KS

Finlay, WJJ (reprint author), UltraHuman Ltd, Codebase, Edinburgh EH3 9DZ, Midlothian, Scotland.

MABS, 2019; 11 (1): 26

Abstract

Monoclonal anti-programmed cell death 1 (PD1) antibodies are successful cancer therapeutics, but it is not well understood why individual antibodies s......

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