Targeting TDO in cancer immunotherapy

Yu, CP; Song, YL; Zhu, ZM; Huang, B; Xiao, YQ; Luo, DY

Luo, DY (reprint author), Nanchang Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Nanchang, Jiangxi, Peoples R China.; Luo, DY (reprint author), Nanchang Univ, Jiangxi Prov Key Lab Tumor Pathogens & Mol Pathol, Nanchang, Jiangxi, Peoples R China.

MEDICAL ONCOLOGY, 2017; 34 (5):

Abstract

Tryptophan-2,3-dioxygenase (TDO) is a homotetrameric heme-containing protein catalyzing the initial step in the kynurenine pathway, which oxidates the......

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