PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells

Viramontes, KM; Neubert, EN; DeRogatis, JM; Tinoco, R

Tinoco, R (通讯作者),Univ Calif Irvine, Sch Biol Sci, Dept Mol Biol & Biochem, Irvine, CA 92697 USA.;Tinoco, R (通讯作者),Univ Calif Irvine, Ctr Virus Res, Irvine, CA 92697 USA.

FRONTIERS IN IMMUNOLOGY, 2022; 13 ():

Abstract

Chronic viral infections where the antigen persists long-term, induces an exhaustion phenotype in responding T cells. It is now evident that immune ch......

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