The LKB1-AMPK-alpha 1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

Moral-Sanz, J; Lewis, SA; Macmillan, S; Ross, FA; Thomson, A; Viollet, B; Foretz, M; Moran, C; Hardie, DG; Evans, AM

Evans, AM (reprint author), Univ Edinburgh, Coll Med & Vet Med, Ctr Discovery Brain Sci & Cardiovasc Sci, Hugh Robson Bldg, Edinburgh EH8 9XD, Midlothian, Scotland.

SCIENCE SIGNALING, 2018; 11 (550):

Abstract

Hypoxic pulmonary vasoconstriction (HPV), which aids ventilation-perfusion matching in the lungs, is triggered by mechanisms intrinsic to pulmonary ar......

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