Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis-MedSci.cn

Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis

Nicolaou, KC; Pan, SY; Pulukuri, KK; Ye, QJ; Rigol, S; Erande, RD; Vourloumis, D; Nocek, BP; Munneke, S; Lyssikatos, J; Valdiosera, A; Gu, C; Lin, BW; Sarvaiaya, H; Trinidad, J; Sandoval, J; Lee, C; Hammond, M; Aujay, M; Taylor, N; Pysz, M; Purcell, JW; Gavrilyuk, J

Nicolaou, KC (corresponding author), Rice Univ, Dept Chem, BioSci Res Collaborat, Houston, TX 77005 USA.

Abstract

Molecular design, synthesis, and biological evaluation of tubulysin analogues, linker-drugs, and antibody-drug conjugates are described. Among the new......

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Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis

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