Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients

Shirakawa, R; Yokota, T; Nakajima, T; Takada, S; Yamane, M; Furihata, T; Maekawa, S; Nambu, H; Katayama, T; Fukushima, A; Saito, A; Ishimori, N; Dela, F; Kinugawa, S; Anzai, T

Yokota, T (reprint author), Hokkaido Univ, Fac Med, Dept Cardiovasc Med, Sapporo, Hokkaido, Japan.; Yokota, T (reprint author), Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan.

SCIENTIFIC REPORTS, 2019; 9 ():

Abstract

Systemic oxidative stress plays a key role in the development of chronic heart failure (CHF). We tested the hypothesis that mitochondrial reactive oxy......

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