Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography

Pan, GD; Munukutla, S; Kar, A; Gardinier, J; Thandavarayan, RA; Palaniyandi, SS

Palaniyandi, SS (reprint author), Henry Ford Hlth Syst, Dept Internal Med, Div Hypertens & Vasc Res, Detroit, MI 48202 USA.; Palaniyandi, SS (reprint author), Wayne State Univ, Dept Physiol, Detroit, MI 48202 USA.

PLOS ONE, 2018; 13 (4):

Abstract

E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabe......

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