Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity

Hafner, M; Mills, CE; Subramanian, K; Chen, C; Chung, M; Boswell, SA; Everley, RA; Liu, CC; Walmsley, CS; Juric, D; Sorger, PK

Juric, D; Sorger, PK (reprint author), Harvard Med Sch, Dept Syst Biol, Lab Syst Pharmacol, Boston, MA 02115 USA.; Juric, D (reprint author), Massachusetts Gen Hosp, Ctr Canc, Termeer Ctr Targeted Therapies, Boston, MA 02114 USA.

CELL CHEMICAL BIOLOGY, 2019; 26 (8): 1067

Abstract

The target profiles of many drugs are established early in their development and are not systematically revisited at the time of FDA approval. Thus, i......

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