Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis

Reynoso, E; Liu, H; Li, L; Yuan, AL; Chen, S; Wang, ZG

Wang, ZG (reprint author), Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017; 292 (42): 17514

Abstract

Necroptosis is an immunogenic cell death program that is associated with a host of human diseases, including inflammation, infections, and cancer. Rec......

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