IFN-alpha confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA

Yuan, Y; Yuan, HF; Yang, G; Yun, HL; Zhao, M; Liu, ZX; Zhao, LN; Geng, Y; Liu, L; Wang, JP; Zhang, HH; Wang, YF; Zhang, XD

Zhang, XD (corresponding author), Nankai Univ, 94 Weijin Rd, Tianjin 300071, Peoples R China.

CLINICAL EPIGENETICS, 2020; 12 (1):

Abstract

Background: Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minic......

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