Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold

Xiong, CD; Zhou, LN; Tan, J; Song, SS; Bao, XB; Zhang, N; Ding, HQ; Zhao, JN; He, JX; Miao, ZH; Zhang, A

He, JX; Miao, ZH; Zhang, A (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China.; Zhang, A (corresponding author), Shanghai Jiao Tong Univ, PharmX Ctr, Sch Pharm, Shanghai 200240, Peoples R China.; He, JX; Miao, ZH; Zhang, A (corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Zhang, A (corresponding author), Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 20

JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (9): 6161

Abstract

The ubiquitin-like protein NEDD8 is a critical signaling molecule implicated in the functional maintenance and homeostasis of cells. Dysregulation of ......

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