BRAF internal deletions and resistance to BRAF/MEK inhibitor therapy

Johnson, DB; Childress, MA; Chalmers, ZR; Frampton, GM; Ali, SM; Rubinstein, SM; Fabrizio, D; Ross, JS; Balasubramanian, S; Miller, VA; Stephens, PJ; Sosman, JA; Lovly, CM

Johnson, DB (reprint author), Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37203 USA.

PIGMENT CELL & MELANOMA RESEARCH, 2018; 31 (3): 432

Abstract

BRAF and MEK inhibitors have improved clinical outcomes in advanced, BRAF(V600)-mutated melanomas. Acquired resistance occurs in most patients, with n......

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