CRISPR-UMI : single-cell lineage tracing of pooled CRISPR-Cas9 screens

Michlits, G; Hubmann, M; Wu, SH; Vainorius, G; Budusan, E; Zhuk, S; Burkard, TR; Novatchkova, M; Aichinger, M; Lu, YQ; Reece-Hoyes, J; Nitsch, R; Schramek, D; Hoepfner, D; Elling, U

Elling, U (reprint author), Austrian Acad Sci IMBA, Inst Mol Biotechnol, Vienna Bioctr VBC, Vienna, Austria.

NATURE METHODS, 2017; 14 (12): 1191

Abstract

Pooled CRISPR screens are a powerful tool for assessments of gene function. However, conventional analysis is based exclusively on the relative abunda......

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