Decarboxylation of Ang-(1-7) to Ala(1)-Ang-(1-7) leads to significant changes in pharmacodynamics

Tetzner, A; Naughton, M; Gebolys, K; Eichhorst, J; Sala, E; Villacanas, O; Walther, T

Walther, T (reprint author), Univ Coll Cork, Sch Med, Dept Pharmacol & Therapeut, Western Gateway Bldg,Western Rd, Cork, Ireland.; Walther, T (reprint author), Univ Coll Cork, Sch Pharm, Western Gateway Bldg,Western Rd, Cork, Ireland.

EUROPEAN JOURNAL OF PHARMACOLOGY, 2018; 833 (): 116

Abstract

The heptapeptide angiotensin (Ang)-(1-7) is part of the beneficial arm of the renin-angiotensin system. Ang(1-7) has cardiovascular protective effects......

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