Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells

Kinehara, Y; Nagatomo, I; Koyama, S; Ito, D; Nojima, S; Kurebayashi, R; Nakanishi, Y; Suga, Y; Nishijima-Futami, Y; Osa, A; Nakatani, T; Kato, Y; Nishide, M; Hayama, Y; Higashiguchi, M; Morimura, O; Miyake, K; Kang, SJ; Minami, T; Hirata, H; Iwahori,

Nagatomo, I; Kumanogoh, A (reprint author), Osaka Univ, Dept Resp Med & Clin Immunol, Grad Sch Med, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan.

JCI INSIGHT, 2018; 3 (24):

Abstract

Although responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) are initially positive, 30%-40% of patients with EGFR-mutant tumors do not respond w......

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