Semisynthesis of the Organoarsenical Antibiotic Arsinothricin

Suzol, SH; Howlader, AH; Galvan, AE; Radhakrishnan, M; Wnuk, SF; Rosen, BP; Yoshinaga, M

Wnuk, SF (corresponding author), Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA.; Yoshinaga, M (corresponding author), Florida Int Univ, Herbert Wertheim Coll Med, Dept Cellular Biol & Pharmacol, Miami, FL 33199 USA.

JOURNAL OF NATURAL PRODUCTS, 2020; 83 (9): 2809

Abstract

Arsinothricin [AST (1)], a new broad-spectrum organoarsenical antibiotic, is a nonproteinogenic analogue of glutamate that effectively inhibits glutam......

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