Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

Alicea, GM; Rebecca, VW; Goldman, AR; Fane, ME; Douglass, SM; Behera, R; Webster, MR; Kugel, CH; Ecker, BL; Caino, MC; Kossenkov, AV; Tang, HY; Frederick, DT; Flaherty, KT; Xu, XW; Liu, Q; Gabrilovich, DI; Herlyn, M; Blair, IA; Schug, ZT; Speicher, DW; Weeraratna, AT

Weeraratna, AT (corresponding author), Johns Hopkins Univ, Sch Publ Heath, 615 N Wolfe St, Baltimore, MD 21205 USA.

CANCER DISCOVERY, 2020; 10 (9): 1282

Abstract

Older patients with melanoma (>50 years old) have poorer prognoses and response rates to targeted therapy compared with young patients (<50 year......

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