BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo

Kumar, K; DeCant, BT; Grippo, PJ; Hwang, RF; Bentrem, DJ; Ebine, K; Munshi, HG

Kumar, K (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Med, 303 E Super Ave,Lurie 3-220, Chicago, IL 60611 USA.; Munshi, HG (reprint author), Northwestern Univ, Dept Med, Feinberg Sch Med, 303 E Super Ave,Lurie 3-117, Chicago, IL 60611 USA.

JCI INSIGHT, 2017; 2 (3):

Abstract

The fibrotic reaction, which can account for over 70%-80% of the tumor mass, is a characteristic feature of human pancreatic ductal adenocarcinoma (PD......

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