Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX

Bozdag, M; Carta, F; Ceruso, M; Ferraroni, M; McDonald, PC; Dedhar, S; Supuran, CT

Supuran, CT (reprint author), Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 3, I-50019 Florence, Italy.

JOURNAL OF MEDICINAL CHEMISTRY, 2018; 61 (14): 6328

Abstract

Herein we report the 2-aminophenol-4-sulfonamide 1 and its ureido derivatives 2-23 as inhibitors of the carbonic anhydrase (CA, EC 4.2.1.1) enzymes as......

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