TAS-120 Overcomes Resistance to ATP-Compartitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholanjiocarcinoma

Goyal, L; Shi, L; Liu, LY; de la Cruz, FF; Lennerz, JK; Raghavan, S; Leschiner, I; Elagina, L; Siravegna, G; Ng, RWS; Vu, P; Patra, KC; Saha, SK; Uppot, RN; Arellano, R; Reyes, S; Sagara, T; Otsuki, S; Nadres, B; Shahzade, HA; DeyGuha, I; Fetter, IJ;

Bardeesy, N (reprint author), Massachusetts Gen Hosp, 185 Cambridge St,CPZN 4216, Boston, MA 02114 USA.; Zhu, AX (reprint author), Massachusetts Gen Hosp Canc Ctr, 55 Fruit St,LH POB 232, Boston, MA 02114 USA.; Corcoran, RB (reprint author), Massachusetts

CANCER DISCOVERY, 2019; 9 (8): 1064

Abstract

ATP-competitive fibroblast growth factor receptor (FGFR) kinase inhibitors, includ- ing BGJ398 and Debio 1347, show antitumor activity in patients wit......

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