PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential

Yadav, L; Pietila, E; Ohman, T; Liu, XN; Mahato, AK; Sidorova, Y; Lehti, K; Saarma, M; Varjosalo, M

Varjosalo, M (corresponding author), Univ Helsinki, Inst Biotechnol, HiLIFE, Syst Biol Pathol Res Grp, FIN-00014 Helsinki, Finland.; Varjosalo, M (corresponding author), Univ Helsinki, Inst Biotechnol, HiLIFE, Prote Unit, FIN-00014 Helsinki, Finland.

ISCIENCE, 2020; 23 (2):

Abstract

The RET proto-oncogene encodes receptor tyrosine kinase, expressed primarily in tissues of neural crest origin. De-regulation of RET signaling is impl......

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