Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer

Jayaraman, S; Hou, XN; Kuffel, MJ; Suman, VJ; Hoskin, TL; Reinicke, KE; Monroe, DG; Kalari, KR; Tang, XJ; Zeldenrust, MA; Cheng, JF; Bruinsma, ES; Buhrow, SA; McGovern, RM; Safgren, SL; Walden, CA; Carter, JM; Reid, JM; Ingle, JN; Ames, MM; Hawse, JR; Goetz, MP

Goetz, MP (corresponding author), Mayo Clin, Dept Oncol, Rochester, MN 55905 USA.; Goetz, MP (corresponding author), Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA.

BREAST CANCER RESEARCH, 2020; 22 (1):

Abstract

Background: The tamoxifen metabolite, Z-endoxifen, demonstrated promising antitumor activity in endocrine-resistant estrogen receptor-positive (ER+) b......

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