Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Freeman-Cook, KD; Hoffman, RL; Behenna, DC; Boras, B; Carelli, J; Diehl, W; Ferre, RA; He, YA; Hui, A; Huang, BW; Huser, N; Jones, R; Kephart, SE; Lapek, J; McTigue, M; Miller, N; Murray, BW; Nagata, A; Nguyen, L; Niessen, S; Ninkovic, S; O'Doherty, I; Ornelas, MA; Solowiej, J; Sutton, SC; Tran, K; Tseng, E; Visswanathan, R; Xu, MR; Zehnder, L; Zhang, Q; Zhang, C; Dann, S

Freeman-Cook, KD (corresponding author), Pfizer Global Res & Dev La Jolla, San Diego, CA 92121 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (13): 9056

Abstract

Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending th......

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