Co-expression IL-15 receptor alpha with IL-15 reduces toxicity via limiting IL-15 systemic exposure during CAR-T immunotherapy

Zhang, Y; Zhuang, QH; Wang, F; Zhang, C; Xu, C; Gu, AQ; Zhong, WH; Hu, Y; Zhong, XS

Zhong, XS (通讯作者),Capital Med Univ, Beijing Shijitan Hosp, Clin Ctr Gene & Cell Engn, 10 Iron Med Rd, Beijing 100038, Peoples R China.;Zhong, XS (通讯作者),Carriage Therapeut Affiliat, Beijing, Peoples R China.

JOURNAL OF TRANSLATIONAL MEDICINE, 2022; 20 (1):

Abstract

Background Chimeric antigen receptor (CAR)-T cell therapy is a powerful adoptive immunotherapy against both B-cell malignancies and some types of soli......

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