Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition

Nobre, L; Zapotocky, M; Ramaswamy, V; Ryall, S; Bennett, J; Alderete, D; Balaguer Guill, J; Baroni, L; Bartels, U; Bavle, A; Bornhorst, M; Boue, DR; Canete, A; Chintagumpala, M; Coven, SL; Cruz, O; Dahiya, S; Dirks, P; Dunkel, IJ; Eisenstat, D; Conter, CF; Finch, E; Finlay, JL; Frappaz, D; Garre, ML; Gauvain, K; Bechensteen, AG; Hansford, JR; Harting, I; Hauser, P; Hazrati, LN; Huang, A; Injac, SG; Iurilli, V; Karajannis, M; Kaur, G; Kyncl, M; Krskova, L; Laperriere, N; Larouche, V; Lassaletta, A; Leary, S; Lin, F; Mascelli, S; McKeown, T; Milde, T; Morales La Madrid, A; Morana, G; Morse, H; Mushtaq, N; Osorio, DS; Packer, R; Pavelka, Z; Quiroga-Cantero, E; Rutka, J; Sabel, M; Salgado, D; Solano, P; Sterba, J; Su, J; Sumerauer, D; Taylor, MD; Toledano, H; Tsang, DS; Valente Fernandes, M; van Landeghem, F; van Tilburg, CM; Wilson, B; Witt, O; Zamecnik, J; Bouffet, E; Hawkins, C; Tabori, U

Hawkins, C (corresponding author), Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.

JCO PRECISION ONCOLOGY, 2020; 4 (): 561

Abstract

PURPOSEChildren with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes with current chemoradiotherapy strategies. Our aim was to st......

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