Epigenetic downregulation of TET3 reduces genome-wide 5hmC levels and promotes glioblastoma tumorigenesis

Carella, A; Tejedor, JR; Garcia, MG; Urdinguio, RG; Bayon, GF; Sierra, M; Lopez, V; Garcia-Torano, E; Santamarina-Ojeda, P; Perez, RF; Bigot, T; Mangas, C; Corte-Torres, MD; Saenz-de-Santa-Maria, I; Mollejo, M; Melendez, B; Astudillo, A; Chiara, MD;

Fernandez, AF; Fraga, MF (reprint author), Ave Roma S-N, Oviedo 33011, Asturias, Spain.

INTERNATIONAL JOURNAL OF CANCER, 2020; 146 (2): 373

Abstract

Loss of 5-hydroxymethylcytosine (5hmC) has been associated with mutations of the ten-eleven translocation (TET) enzymes in several types of cancer. Ho......

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