Conformational Landscapes of HER2 Exon 20 Insertions Explain Their Sensitivity to Kinase Inhibitors in Lung Adenocarcinoma

Zhao, S; Fang, WF; Pan, H; Yang, YP; Liang, Y; Yang, L; Dong, XR; Zhan, JH; Wang, K; Zhang, L

Zhang, L (corresponding author), Sun Yat Sen Univ, Canc Ctr, Dept Med Oncol, 651 Dongfeng East Rd, Guangzhou 510060, Peoples R China.

JOURNAL OF THORACIC ONCOLOGY, 2020; 15 (6): 962

Abstract

Introduction: HER2 exon 20 insertion (ex20ins) is one of the most intractable problems in lung cancer. Most ex20ins are resistant to available EGFR or......

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