Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation

Ekanayaka, P; Lee, SY; Herath, TUB; Kim, JH; Kim, TH; Lee, H; Chathuranga, K; Chathuranga, WAG; Park, JH; Lee, JS

Lee, JS (corresponding author), Chungnam Natl Univ, Coll Vet Med, Daejeon, South Korea.; Park, JH (corresponding author), Anim & Plant Quarantine Agcy, Gyeongsangbuk Do, South Korea.; Park, JH; Lee, JS (corresponding author), Univ Calif Berkeley, Calif Inst Quantitat Biosci, Berkeley, CA 94720 USA.

PLOS PATHOGENS, 2020; 16 (11):

Abstract

VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral ......

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