APOE-c4 synergizes with sleep disruption to accelerate Ap deposition and Ap-associated tau seeding and spreading

Wang, CN; Nambiar, A; Strickland, MR; Lee, CH; Parhizkar, S; Moore, AC; Musiek, ES; Ulrich, JD; Holtzman, DM

Holtzman, DM (通讯作者)，Washington Univ, Hope Ctr Neurol Disorders, Knight Alzheimers Dis Res Ctr, Sch Med,Dept Neurol, 660 S Euclid Ave, POB 8111, St. Louis, MO 63110 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (14):

Abstract

Alzheimer's disease (AD) is the most common cause of dementia. The APOE-c4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk fa......

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