Serine-Selective Bioconjugation

Vantourout, JC; Adusumalli, SR; Knouse, KW; Flood, DT; Ramirez, A; Padial, NM; Istrate, A; Maziarz, K; DeGruyter, JN; Merchant, RR; Qiao, JX; Schmidt, MA; Deery, MJ; Eastgate, MD; Dawson, PE; Bernardes, GJL; Baran, PS

Dawson, PE; Baran, PS (corresponding author), Scripps Res, Dept Chem, La Jolla, CA 92037 USA.; Bernardes, GJL (corresponding author), Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England.; Eastgate, MD (corresponding author), Bristol Myers Squibb Co, Chem Proc Dev, New Brunswick, NJ 08903 USA.; Bernardes, GJL (corresponding author), Univ Lisbon, Fac Med, Inst Med Mol, P-1649028 Lisbon, Portugal.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020; 142 (41): 17236

Abstract

This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides......

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