PK/PD modeling of a clazosentan thorough QT study with hysteresis in concentration-QT and RR-QT

Henrich, A; Juif, PE; Dingemanse, J; Krause, A

Krause, A (corresponding author), Idorsia Pharmaceut Ltd, Dept Clin Pharmacol, Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, ; ():

Abstract

Clazosentan's potential QT liability was investigated in a thorough QT study in which clazosentan was administered intravenously as a continuous infus......

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