TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis

Brauneck, F; Fischer, B; Witt, M; Muschhammer, J; Oelrich, J; Avelar, PHD; Tsoka, S; Bullinger, L; Seubert, E; Smit, DJ; Bokemeyer, C; Ackermann, C; Wellbrock, J; Haag, F; Fiedler, W

Brauneck, F (通讯作者)，Univ Med Ctr Hamburg Eppendorf, Hubertus Wald Univ Canc Ctr, Dept Oncol Hematol & Bone Marrow Transplantat Sect, Hamburg, Germany.;Brauneck, F (通讯作者)，Univ Med Ctr Hamburg Eppendorf, Mildred Scheel Canc Career Ctr HaTriCS4, Hamburg, Germany.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022; 10 (12):

Abstract

BackgroundLeukemia-associated macrophages (LAMs) represent an important cell population within the tumor microenvironment, but little is known about t......

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