Murine IL-4 Delta 2 splice variant down-regulates IL-4 activities independently of IL-4R alpha binding and STAT-6 phosphorylation

Diogo, GR; Sparrow, A; Paul, MJ; Copland, A; Hart, PJ; Stelter, S; van Dolleweerd, C; Drake, PMW; Macallan, DC; Reljic, R

Reljic, R (reprint author), St Georges Univ London, Inst Infect & Immun, Cranmer Terrace, London SW17 0RE, England.

CYTOKINE, 2017; 99 ( ): 154

Abstract

IL-4 is a pleiotropic cytokine that is highly Th2 polarizing. The ratio of IL-4 and its splice variant IL-4 Delta 2 observed in human health and disea......

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