Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors

Pathak, R; Zin, F; Thomas, C; Bens, S; Gayden, T; Karamchandani, J; Dudley, RW; Nemes, K; Johann, PD; Oyen, F; Kordes, U; Jabado, N; Siebert, R; Paulus, W; Kool, M; Fruhwald, MC; Albrecht, S; Kalpana, GV; Hasselblatt, M

Kalpana, GV (corresponding author), Albert Einstein Coll Med, Dept Genet & Microbiol, New York, NY 10461 USA.; Kalpana, GV (corresponding author), Albert Einstein Coll Med, Dept Immunol, New York, NY 10461 USA.; Hasselblatt, M (corresponding author), Univ Hosp Munster, Inst Neuropathol, Pottkamp 2, D-48149 Munster, Germany.

ACTA NEUROPATHOLOGICA, 2021; 142 (2): 361

Abstract

Loss of nuclear SMARCB1 (INI1/hSNF5/BAF47) protein expression due to biallelic mutations of the SMARCB1 tumor suppressor gene is a hallmark of atypica......

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