AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arrest in Chronic and Acute Myeloid Leukemia Cells

Lapa, BS; Costa, MI; Figueiredo, D; Jorge, J; Alves, R; Monteiro, AR; Serambeque, B; Laranjo, M; Botelho, MF; Carreira, IM; Sarmento-Ribeiro, AB; Goncalves, AC

Goncalves, AC (通讯作者)，Univ Coimbra, Univ Clin Hematol & Oncol, Fac Med FMUC, Lab Oncobiol & Hematol LOH, P-3000548 Coimbra, Portugal.;Goncalves, AC (通讯作者)，Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Goncalves, AC (通讯作者)，Ctr Innovat Biomed & Biotechnol CIBB, P-3004504 Coimbra, Portugal.;Goncalves, AC (通讯作者)，Clin Acad Ctr Coimbra CACC, P-3000061 Coimbra, Portugal.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023; 24 (20):

Abstract

The non-homologous end joining pathway is vital for repairing DNA double-strand breaks (DSB), with DNA-dependent protein kinase (DNA-PK) playing a cri......

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