Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

Darwish, S; Ghazy, E; Heimburg, T; Herp, D; Zeyen, P; Salem-Altintas, R; Ridinger, J; Robaa, D; Schmidtkunz, K; Erdmann, F; Schmidt, M; Romier, C; Jung, M; Oehme, I; Sippl, W

Sippl, W (通讯作者),Martin Luther Univ Halle Wittenberg, Inst Pharm, Dept Med Chem, D-06120 Halle, Saale, Germany.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022; 23 (14):

Abstract

In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the acti......

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