Damage sensor role of UV-DDB during base excision repair

Jang, S; Kumar, N; Beckwitt, EC; Kong, M; Fouquerel, E; Rapic-Otrin, V; Prasad, R; Watkins, SC; Khuu, C; Majumdar, C; David, SS; Wilson, SH; Bruchez, MP; Opresko, PL; Van Houten, B

Van Houten, B (reprint author), Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA.; Van Houten, B (reprint author), Univ Pittsburgh, UPMC Hillman Canc Ctr, Pittsburgh, PA 15213 USA.; Van Houten, B (reprint author), Univ Pittsb

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2019; 26 (8): 695

Abstract

UV-DDB, a key protein in human global nucleotide excision repair (NER), binds avidly to abasic sites and 8-oxo-guanine (8-oxoG), suggesting a noncanon......

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