Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2

Thavalingam, A; Cheng, Z; Garcia, B; Huang, X; Shah, M; Sung, W; Wang, M; Harrington, L; Hwang, SW; Hidalgo-Reyes, Y; Sontheimer, EJ; Doudna, J; Davidson, AR; Moraes, TF; Wang, YL; Maxwell, KL

Maxwell, KL (reprint author), Univ Toronto, Dept Biochem, 661 Univ Ave,Suite 1600, Toronto, ON M5G 1M1, Canada.; Wang, YL (reprint author), Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Key Lab RNA Biol, Beijing 100101, Peoples R China.;

NATURE COMMUNICATIONS, 2019; 10 ():

Abstract

CRISPR-Cas adaptive immune systems function to protect bacteria from invasion by foreign genetic elements. The CRISPR-Cas9 system has been widely adop......

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