Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR gamma t Allosteric Inhibitors for Autoimmune Diseases

Zhang, HJ; Lapointe, BT; Anthony, N; Azevedo, R; Cals, J; Correll, CC; Daniels, M; Deshmukh, S; van Eenenaam, H; Ferguson, H; Hegde, LG; Karstens, WJ; Maclean, J; Miller, JR; Moy, LY; Simov, V; Nagpal, S; Oubrie, A; Palte, RL; Parthasarathy, G; Sciammetta, N; van der Stelt, M; Woodhouse, JD; Trotter, BW; Barr, K

Zhang, HJ (corresponding author), Merck & Co Inc, Boston, MA 02115 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2020; 11 (2): 114

Abstract

The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimm......

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