4,6-Substituted-1 H-Indazoles as potent IDO1/TDO dual inhibitors

Yang, LL; Chen, Y; He, JL; Njoya, EM; Chen, JJ; Liu, SY; Xie, CQ; Huang, WZ; Wang, F; Wang, ZY; Li, YZ; Qian, S

Wang, ZY; Qian, S (reprint author), Xihua Univ, Sch Food & Bioengn, Dept Pharmaceut Engn, Chengdu 610039, Sichuan, Peoples R China.; Li, YZ (reprint author), Chengdu Univ Tradit Chinese Med, Coll Pharm, Key Lab Systemat Res Dev & Utilizat Chinese Med R, C

BIOORGANIC & MEDICINAL CHEMISTRY, 2019; 27 (6): 1087

Abstract

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert imp......

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