Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

Heintz, C; Doktor, TK; Lanjuin, A; Escoubas, CC; Zhang, Y; Weir, HJ; Dutta, S; Silva-Garcia, CG; Bruun, GH; Morantte, I; Hoxhaj, G; Manning, BD; Andresen, BS; Mair, WB

Mair, WB (reprint author), Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA.

NATURE, 2017; 541 (7635): 102

Abstract

Ageing is driven by a loss of transcriptional and protein homeostasis(1-3) and is the key risk factor for multiple chronic diseases. Interventions tha......

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